Plasma Nonesterified Fatty Acid Concentration as a Risk Factor for Sudden Cardiac Death

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Plasma nonesterified fatty acid concentration as a risk factor for sudden cardiac death: the Paris Prospective Study.

In the 1960s and 1970s, at the time the study by Jouven et al1 was initiated, there was much interest among cardiologists regarding the likelihood that elevated concentrations of free fatty acids in plasma occurring with myocardial ischemia might initiate ventricular arrhythmias resulting in sudden cardiac death. Nevertheless, it required far-sighted investigators to launch an epidemiological s...

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Circulating nonesterified fatty acid level as a predictive risk factor for sudden death in the population.

BACKGROUND In ischemic conditions, concentration of circulating nonesterified fatty acids (NEFA) is increased and has a proarrhythmic effect that is responsible for ventricular tachyarrhythmias. In nonischemic patients, high NEFA plasma concentration has been shown to be associated with frequent premature ventricular complexes and increased familial risk of cardiovascular disease, but its relat...

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Nonesterified fatty acids and risk of sudden cardiac death in older adults.

BACKGROUND Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death. METHODS AND RESULTS Using a prospective design, we studied 4657 older men and women (mean age, 75 years) from the Cardiovascular Health Study (1992-2006) to evaluate the...

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Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults

Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated throu...

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Heart rate variability as predictive factor for sudden cardiac death

Sudden cardiac death (SCD) represents about 25% of deaths in clinical cardiology. The identification of risk factors for SCD is the philosopher's stone of cardiology and the identification of non-invasive markers of risk of SCD remains one of the most important goals for the scientific community.The aim of this review is to analyze the state of the art around the heart rate variability (HRV) as...

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ژورنال

عنوان ژورنال: Circulation

سال: 2001

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.104.7.744